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Supremmune is a top-down arena game where you play as an immune cell fighting off bacteria and viruses. Earn DNA from battles to buy weapons and items, enhancing each cell's abilities. Make strategic choices to survive unexpected challenges. Evolve into a powerful cell, defeat enemies, and win!
PC (Microsoft Windows) · Sep 2, 2025
Worldwide · Exact date · Early access · IGDB
PC (Microsoft Windows) · Jun 30, 2026
Worldwide · Exact date · Full release · IGDB
Catalog sources
76 achievements available.

Reach 144% Attack Speed
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Complete cycle with character Caller
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Destroy Cell Prison 50 times (cumulative)
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Complete cycle with character Cloudy
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Collide with enemies 50 times (cumulative)
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Complete cycle with character Crashy
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Achieve Data Gathering 100
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Reach 40% Data Replication
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Die on the next wave after obtaining "Deal with the Devil"
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Complete cycle with character Droppy
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Achieve Visibility 1 with [Droppy]
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Die from single hit when current HP is 50+
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Die 3 times in Difficulty 1
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Clear Difficulty 1
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Clear Difficulty 2
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Clear Difficulty 3
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Clear Difficulty 4
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Complete cycle with character Digmo
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Destroy 1 calculi in one cycle with [Digmo]
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Destroy 2 calculi in one cycle with [Digmo]
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Destroy 3 calculi in one cycle with [Digmo]
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Reach 60% Dodge
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Die while Dodge is 60% or higher
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Dodge 10 times in a row
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Complete cycle with character Doubly
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Complete cycle with character Dr.Sprout
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Clear Wave Event "Fatigue"
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Complete cycle with character GuiGui
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Deal 5000+ damage in a single hit
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Possess 20+ items
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Complete cycle with character Jackpotpot
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Complete cycle with character Joanie
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Destroy 100 cell prisons in one cycle with [Joanie]
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Defeat 100 enemies
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Defeat 1000 enemies
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Defeat 10000 enemies
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Defeat an Elite
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Reach Level 20
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Achieve Luck 200
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Complete cycle with character Luckster
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Complete cycle with character Burny
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Possess 6 Melee Weapons
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Complete cycle with character Munchy
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Clear 3 consecutive waves without moving
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Start wave without possessing any weapon
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Complete cycle with character O.P.
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Critical Chance exceeds 100%
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Possess 6 Ranged Weapons
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Complete cycle with character SASA44
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Reach 50 Shield
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Complete cycle with character Sprouty
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Clear Difficulty 4 with character Caller
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Clear Difficulty 4 with character Cloudy
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Clear Difficulty 4 with character Crashy
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Clear Difficulty 4 with character Droppy
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Clear Difficulty 4 with character Digmo
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Clear Difficulty 4 with character Doubly
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Clear Difficulty 4 with character Dr.Sprout
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Clear Difficulty 4 with character GuiGui
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Clear Difficulty 4 with character Jackpotpot
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Clear Difficulty 4 with character Joanie
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Clear Difficulty 4 with character Luckster
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Clear Difficulty 4 with character Burny
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Clear Difficulty 4 with character Munchy
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Clear Difficulty 4 with character O.P.
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Clear Difficulty 4 with character SASA44
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Clear Difficulty 4 with character Sprouty
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Clear Difficulty 4 with character Swipy
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Clear Difficulty 4 with character Zapbean
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Interact with Supply Bot 10 times (cumulative)
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Clear Difficulty 4 with all characters
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Complete cycle with all characters
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Complete cycle with character Swipy
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Wait 5 minutes on result screen
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Wait 5 minutes on title screen
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Complete cycle with character Zapbean
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Community notes