By: Alpherior
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COMBINE WEAPONS in the microscopic shooter with macroscopic depth. BUILD YOUR NANOBOT from hundreds of parts. SURVIVE the microbial onslaught once more in this psychedelic dive to the Abyss, full of mutations, minerals, anomalies and powerup polyps. SHMUP mode turns it into a vertical shoot 'em up!
PC (Microsoft Windows) · Mar 5, 2026
Worldwide · Exact date · Early access · IGDB
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100 achievements available.

welcome to Genome Guardian 2!
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achieve victory in BROOD Mode at DEPTH 1.
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achieve victory with all Mods at DEPTH 5.
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achieve victory in BROOD Mode at DEPTH 3.
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achieve victory in BROOD Mode at DEPTH 5.
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unlock 48 Mods.
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achieve victory in MINER Mode at DEPTH 1.
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achieve victory in MINER Mode at DEPTH 3.
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achieve victory in MINER Mode at DEPTH 5.
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defeat The Abyss.
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achieve victory in GHOST Mode at DEPTH 1.
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achieve victory in GHOST Mode at DEPTH 3.
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achieve victory in VIRUS Mode at DEPTH 1.
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achieve victory in GHOST Mode at DEPTH 5.
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achieve victory in VIRUS Mode.
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achieve victory in SHMUP Mode at DEPTH 1.
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achieve victory in SHMUP Mode at DEPTH 3.
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achieve victory in SHMUP Mode at DEPTH 5.
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unlock 12 of 24 Guardians.
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unlock 6 of 12 Hulls.
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unlock 6 of 12 Platforms.
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unlock 6 of 12 Barrels.
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unlock 6 of 12 Brackets.
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achieve victory in VIRUS Mode at DEPTH 3.
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unlock 6 of 12 Cores.
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unlock 6 of 12 Motherboards.
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unlock 48 of 96 Mods.
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unlock 6 of 12 Gadgets.
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eliminate 3000 Microbes with Proximity weapons.
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eliminate 3000 Microbes with Burn weapons.
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eliminate 3000 Microbes with Homing weapons.
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eliminate 3000 Microbes with Explosive weapons.
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eliminate 3000 Microbes with Area weapons.
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eliminate 3000 Microbes with Flak weapons.
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achieve victory in VIRUS Mode at DEPTH 5.
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eliminate 3000 Microbes with Split weapons.
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eliminate 3000 Microbes with Pierce weapons.
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eliminate 3000 Microbes with Freeze weapons.
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eliminate 3000 Microbes with Hitscan weapons.
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eliminate 3000 Microbes with Zap weapons.
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eliminate 3000 Microbes with Burst Fire weapons.
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eliminate 3000 Microbes with Sticky weapons.
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eliminate 3000 Microbes with Bounce weapons.
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complete 1 dive.
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visit the Discord via the in-game button on the Main Menu.
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complete all Research on the "BUFFS" page in the Research menu.
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use Platforms with Speed to travel 3mm.
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read every Microbe description in the Database.
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achieve victory with the Jester Guardian.
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fire 3000000 projectiles.
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Burn 10000 Microbes.
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Freeze 10000 Microbes.
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land 30000 Crit hits.
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eliminate 30000 Microbes.
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eliminate 3000 Exalted Microbes.
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eliminate 1000 Enraged Microbes.
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achieve victory in DRAFT Mode at DEPTH 1.
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eliminate 1000 Microbes with Knockback by pushing them past 200% Range.
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purchase 1000 shop offers.
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Bleach 100 shop Genes.
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Reroll the shop 300 times.
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Banish 300 shop offers.
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mine 100 Deposits.
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trigger 1000 Powerpolyps.
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gain 30000 Biomass.
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gain 100000 Research.
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endure 100 Mutations.
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achieve victory in DRAFT Mode at DEPTH 3.
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experience 30 Anomalies.
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complete 100 Studies.
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use Gadgets 300 times.
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survive wave 100.
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survive 1000 waves.
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complete 100 dives.
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achieve 30 victories.
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discover all weapons.
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discover all Genes.
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discover all Chips.
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achieve victory in DRAFT Mode at DEPTH 5.
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discover all Mutations.
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achieve victory with all weapons.
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achieve victory with all Gadgets.
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achieve victory with all weapons at DEPTH 5.
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achieve victory with all Gadgets at DEPTH 5.
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achieve victory with all Guardians.
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achieve victory with all Hulls.
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achieve victory with all Platforms.
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achieve victory with all Barrels.
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achieve victory with all Brackets.
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discover all Microbes.
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achieve victory with all Cores.
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achieve victory with all Motherboards.
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achieve victory with all Mods.
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achieve victory with all Guardians at DEPTH 5.
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achieve victory with all Hulls at DEPTH 5.
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achieve victory with all Platforms at DEPTH 5.
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achieve victory with all Barrels at DEPTH 5.
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achieve victory with all Brackets at DEPTH 5.
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achieve victory with all Cores at DEPTH 5.
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achieve victory with all Motherboards at DEPTH 5.
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