By: Alpherior
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Genome Guardian is a top-down roguelite turret shooter where you must defend yourself from hostile aliens at the microscopic level. Combine & discover 70 weapons across 4 modes using a vast array of turrets, perks, modifiers and power-ups on this vibrant journey to the depths of the abyss.
PC (Microsoft Windows) · May 7, 2024
Worldwide · Exact date · Full release · IGDB
Nintendo Switch · Feb 6, 2025
Worldwide · Exact date · Full release · IGDB
Catalog sources
100 achievements available.

Welcome to Genome Guardian!
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Achieve victory in Classic mode at Depth 1.
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Have 200 Health (or more) during a run.
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Have 300 Health Max (or more) during a run.
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Have 30 Shield (or more) during a run.
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Have 300 Heat Max (or more) during a run.
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Have 500% Critical Damage (or more) during a run.
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Have 900% Power-up Chance (or more) during a run.
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Have 3000 unspent Biomass (or more) during a run.
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Have 10000 unspent Research (or more).
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Achieve victory in Classic mode at Depth 2.
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Have a weapon with 1000 DPS (or more) during a run. (honestly this might not trigger on complex weapons with unique functions)
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Have a weapon with 1000 Damage (or more) on a single projectile during a run.
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Have a weapon with 1000 Knockback (or more) during a run.
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Have a weapon with 60/s Firerate during a run.
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Have a weapon with 1000 Speed (or more) during a run.
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Have 1 of each starter weapon mounted at the same time.
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Have 3 of the same tier-4 weapon on a turret with 3 weapon mounts during a run.
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Synthesize the same weapon 100 times.
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Eliminate 30000 microbes.
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Play 100 runs.
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Achieve victory in Classic mode at Depth 3.
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Buy 500 items from the shop.
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Reroll the shop 300 times.
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View the credits via the ? button on the main menu.
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Reduce wave time by 15s during a run.
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Survive wave 3 before having fired any weapon.
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Survive wave 100 in any mode.
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Achieve victory in any mode with the Scorch turret and the Funnel perk.
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Achieve victory in any mode with the Diesel turret and the Funnel perk.
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Achieve victory in any mode with the Buckler turret and the Magnifier, Reactor and Chitin perks.
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Achieve victory in any mode with the Surge turret and the Firewall perk.
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Achieve victory in Classic mode at Depth 4.
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Achieve victory in any mode with the Colossus turret and the Hourglass perk.
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Achieve victory in any mode with the Satellite turret and the Nitro, Mirror and Balloon perks.
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Achieve victory in any mode with the Daisy turret and the Prism perk.
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Achieve(?) defeat in any mode via turret destruction within 4s.
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Achieve victory in any mode where only microbes with A DNA aren't extinct.
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Achieve victory in any mode where only microbes with C DNA aren't extinct.
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Achieve victory in any mode where only microbes with G DNA aren't extinct.
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Achieve victory in any mode where only microbes with T DNA aren't extinct.
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Achieve victory in any mode without taking a single hit.
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Achieve victory in Classic mode at Depth 5.
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Achieve victory in any mode without any perks.
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Achieve victory in any mode without any weapon mods.
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Achieve victory in any mode without any turret mods.
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Achieve victory in any mode 30 times.
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Achieve victory in any mode with all turrets.
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Achieve victory in any mode at Depth 5 with all turrets.
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Achieve victory in any mode with all perks.
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Achieve victory in any mode at Depth 5 with all perks.
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Achieve victory in any mode with all weapons.
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Achieve victory in Brood mode at Surface Depth.
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Achieve victory in Brood mode at Depth 1.
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Achieve victory in Brood mode at Depth 2.
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Achieve victory in Brood mode at Depth 3.
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Achieve victory in Extract mode at Surface Depth.
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Achieve victory in Brood mode at Depth 4.
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Achieve victory in Brood mode at Depth 5.
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Achieve victory in Abyss mode at Surface Depth.
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Achieve victory in Abyss mode at Depth 1.
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Achieve victory in Abyss mode at Depth 2.
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Achieve victory in Abyss mode at Depth 3.
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Achieve victory in Abyss mode at Depth 4.
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Achieve victory in Abyss mode at Depth 5.
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Welcome to Genome Guardian!
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Achieve victory in Extract mode at Depth 1.
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Research for ◇400.
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Research for ◇400.
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Research for ◇400.
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Achieve victory in any mode 10 times.
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Achieve victory in Extract mode.
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Eliminate 6666 microbes.
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Discover all 69 microbes.
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Achieve victory in any mode at Depth 3.
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Achieve victory in any mode at Depth 1 (or deeper) with the Reactor perk.
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Achieve victory in Extract mode at Depth 2.
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Achieve victory in any mode at Depth 3 (or deeper) with both the Thermometer perk and Extinguisher perk at the same time.
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Achieve victory in any mode with 30 different weapons.
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Synthesize all 69 weapons at least once.
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Survive wave 50 in any mode at Depth 3 (or deeper).
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Achieve victory in Classic mode at Depth 5.
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Achieve victory in Brood mode at Depth 5.
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Trigger 300 power-ups.
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Achieve victory in Extract mode at Depth 3.
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Achieve victory at Depth 3 (or deeper) with a pinpoint or better than 2° Accuracy weapon.
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Achieve victory in any mode at Depth 3 (or deeper) with a weapon that has 360° Accuracy.
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Achieve victory in any mode with 30 different perks.
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Achieve victory in any mode at Depth 3 (or deeper) with a Burn weapon that didn't originally have Burn.
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Achieve victory in Extract mode at Depth 4.
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Achieve victory in Extract mode at Depth 5.
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Achieve victory in Classic mode at Surface Depth.
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Community notes